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Alopecia totalis

Field	Value
name	Alopecia totalis
image	AlopeciaTotalis.jpg
caption	A woman with alopecia totalis

Alopecia totalis is the loss of all hair on the head and face. Its causes are unclear, but it is believed to be an autoimmune disorder. Research suggests there may be a genetic link: the presence of DRB10401 and DQB10301, both of which are human leukocyte antigens (HLA), have been found to be associated with long-standing alopecia totalis.

Treatment

Methotrexate and corticosteroids are proposed treatments.

Scalp cooling has specifically been used to prevent alopecia in docetaxel chemotherapy, although it has been found prophylactic in other regimens as well. Treatment effects may take time to resolve, with one study showing breast cancer survivors wearing wigs up to 2 years after chemotherapy.

References

(December 1999). "The Genetic Basis of Alopecia Areata: HLA Associations with Patchy Alopecia Areata Versus Alopecia Totalis and Alopecia Universalis". Journal of Investigative Dermatology Symposium Proceedings.
(2006). "The use of methtrexate alone or in combination with low doses of oral corticosteroids in the treatment of alopecia totalis or universalis". Journal of the American Academy of Dermatology.
(2012). "Short post-infusion scalp cooling time in the prevention of docetaxel-induced alopecia". Supportive Care in Cancer.
(2012). "Reducing chemotherapy-induced alopecia with scalp cooling". Clinical Advances in Hematology & Oncology.
(2012). "Scalp cooling for hair preservation and associated characteristics in 1411 chemotherapy patients - Results of the Dutch Scalp Cooling Registry". Acta Oncologica.
(2011). "Treatment of chemotherapy-induced alopecia". Dermatologic Therapy.
(2012). "A questionnaire survey about hair loss after chemotherapy for breast cancer". Gan to Kagaku Ryoho. Cancer & Chemotherapy.

Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

conditions-of-the-skin-appendages human-hair hair-diseases

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