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Alimemazine

Chemical compound

Chemical compound

FieldValue
Watchedfieldschanged
verifiedrevid477317349
imageAlimemazine.svg
image_classskin-invert-image
image2Alimemazine Tartrate 10mg.jpg
USANtrimeprazine
BANtrimeprazine
Drugs.com
DailyMedIDTrimeprazine
pregnancy_AUC
routes_of_administrationBy mouth
classAnti-allergic agent
ATC_prefixR06
ATC_suffixAD01
legal_AUSchedule 4
legal_AU_comment/Schedule 3; Schedule 2; Appendix K, clause 1
legal_UKPOM
legal_USRx-only
legal_US_comment
metabolismLiver
elimination_half-life4.78 ± 0.59 hours
IUPHAR_ligand7237
CAS_number_Ref
CAS_number84-96-8
PubChem5574
DrugBank_Ref
DrugBankDB01246
ChemSpiderID_Ref
ChemSpiderID5373
UNII_Ref
UNII76H78MJJ52
UNII2362NW1LD6Z
KEGG_Ref
KEGGD07125
KEGG2D02245
ChEMBL_Ref
ChEMBL829
synonyms
IUPAC_nameN,N,2-trimethyl-3-phenothiazin-10-yl-propan-1-amine
C18H=22N=2S=1
smilesS2c1ccccc1N(c3c2cccc3)CC(C)CN(C)C
StdInChI_Ref
StdInChI1S/C18H22N2S/c1-14(12-19(2)3)13-20-15-8-4-6-10-17(15)21-18-11-7-5-9-16(18)20/h4-11,14H,12-13H2,1-3H3
StdInChIKey_Ref
StdInChIKeyZZHLYYDVIOPZBE-UHFFFAOYSA-N

| Drugs.com =

| elimination_half-life = 4.78 ± 0.59 hours

Alimemazine (INN), also known as trimeprazine, commonly provided as a tartrate salt, is a phenothiazine derivative that is used as an antipruritic (it prevents itching from causes such as eczema or poison ivy, by acting as an antihistamine). It also acts as a sedative, hypnotic, and antiemetic for prevention of motion sickness.

Despite being structurally related to the molecule chlorpromazine, it is not used as an antipsychotic.

Society and culture

Brand names

Brand names include Nedeltran, Panectyl, Repeltin, Teraligen, Therafene, Theraligene, Theralen, Thegalin, Theralene, Vallergan, Vanectyl, and Temaril.

Use by Country

In the Russian Federation, it is sold under the brand name Teraligen for the treatment of anxiety disorders (including GAD), organic mood disorders, sleep disturbances, personality disorders accompanied by asthenia and depression, somatoform autonomic dysfunction and various neuroses.

Veterinary use

In the United States, the Food and Drug Administration (FDA) has not approved it for human use, and it can only be prescribed by veterinarians.

A novel combination drug that combines alimemazine with prednisolone and sold under the brand name Temaril-P is licensed as an antipruritic and antitussive in dogs (called Vanectyl P in Canada). A generic version of the combination trimeprazine/prednisolone was approved by the US Food and Drug Administration (FDA) in June 2024.

References

References

  1. (May 2025). "Therapeutic Goods (Poisons Standard— June 2025) Instrument 2025".
  2. (14 March 2019). "Trimeprazine tartrate powder".
  3. (March 1986). "Relative bioavailability of trimeprazine tablets investigated in man using HPLC with electrochemical detection". The Journal of Pharmacy and Pharmacology.
  4. "(3R,4R)-3,4-dihydroxyhexane-2,5-dione;N,N,2-trimethyl-3-phenothiazin-10-ylpropan-1-amine".
  5. "Alimemazine".
  6. "Тералиджен — инструкция по применению, дозы, побочные действия, описание препарата: таблетки, покрытые пленочной оболочкой,раствор для внутримышечного введения, 5 мг/мл, 5 мг".
  7. (12 January 2023). "Temaril-P- trimeprazine tartrate and prednisolone tablet".
  8. (21 June 2024). "FDA Roundup: June 21, 2024".
  9. "FOI Summary for the Original Approval of ANADA 200-784". United States Food and Drug Administration.
Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

antiemetics phenothiazines h1-receptor-antagonists
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