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Alezzandrini syndrome

Field	Value
name	Alezzandrini syndrome
image	Alezzandrini syndrome hariadhi.svg
field	Dermatology
symptoms	Loss of vision, facial vitiligo, sound sensitivity
causes	Unknown
treatment	None
deaths	Unknown

Alezzandrini syndrome is a very rare syndrome characterized by a unilateral degenerative retinitis, followed after several months by ipsilateral vitiligo on the face and ipsilateral poliosis. Deafness may also be present.

Signs and symptoms

Initially, there is a progressive loss of visual acuity, mostly in one eye. Infected areas experience pigmentation loss in the skin and hair. Unilateral tapetoretinal degeneration accompanied by the ipsilateral appearance of facial vitiligo and poliosis is the hallmark of Alezzandrini syndrome.

Causes

It is unknown what causes Alezzandrini syndrome.

Diagnosis

The clinical presentation is the basis for the diagnosis.

Treatment

Psoralen plus ultraviolet A (PUVA) treatment is an option for cases with extensive depigmentation. Topical steroids may be used to treat vitiligo in specific areas. People who have vitiligo should wear sunscreen to avoid getting sunburned and developing skin cancer later on.

References

(2005). "Andrews' Diseases of the Skin: Clinical Dermatology". Saunders.
(August 2011). "Alezzandrini syndrome". BMJ Case Reports.
(2007). "Dermatology: 2-Volume Set". Mosby.
Janniger, Camila K. (June 8, 2022). "Alezzandrini Syndrome: Practice Essentials, Pathophysiology, Epidemiology".

Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

disturbances-of-human-pigmentation rare-syndromes syndromes-affecting-the-retina syndromes-affecting-hearing syndromes-affecting-the-skin

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