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Adenovirus vaccine
| Field | Value |
|---|---|
| type | vaccine |
| image | TEVA adenovirus.jpg |
| caption | Bottles of the vaccine |
| target | Adenovirus |
| vaccine_type | Live virus |
| Drugs.com | |
| DailyMedID | Adenovirus type |
| pregnancy_AU | |
| routes_of_administration | Oral administration |
| ATC_prefix | None |
| legal_AU | |
| legal_BR | |
| legal_CA | |
| legal_DE | |
| legal_NZ | |
| legal_UK | |
| legal_US | Rx-only |
| legal_US_comment | |
| legal_UN | |
| legal_status | |
| DrugBank | DB14409 |
| UNII | FKD3DUK39I |
| UNII2 | TM54L796SN |
vaccination against adenoviruses
| Drugs.com =
| elimination_half-life =
An adenovirus vaccine is a vaccine against adenovirus infection. According to the American CDC, "There is currently no adenovirus vaccine available to the general public.
It should not be confused with the strategy of using adenovirus as a viral vector to develop vaccines for other pathogens, or as a general gene carrier.
US military
It was used by the United States military from 1971 to 1999, but was discontinued when the only manufacturer stopped production. This vaccine elicited immunity to adenovirus serotypes 4 and 7, the serotypes most often associated with acute respiratory disease. On 16 March 2011, the U.S. Food and Drug Administration approved an adenovirus vaccine manufactured by Teva Pharmaceuticals under contract to the U.S. Army. This vaccine is essentially the same as the one used from 1971 to 1999. On 24 October 2011, the military services began administering the new adenovirus vaccine to recruits during basic training.
The vaccine is orally administered and consists of live (not attenuated) virus. The tablets are coated, so that the virus passes the stomach and infects the intestines, where the immune response is raised.
References
References
- (26 July 2022). "Adenovirus Type 4 and Type 7 Vaccine, Live kit".
- (15 October 2019). "Adenovirus Type 4 and Type 7 Vaccine, Live, Oral".
- (February 2008). "Oral adenoviral-based vaccines: historical perspective and future opportunity". Expert Rev Vaccines.
- (2023-04-27). "Adenovirus Vaccine Information Statement {{!}} CDC".
- (2008). "Nasal Delivery of an Adenovirus-Based Vaccine Bypasses Pre-Existing Immunity to the Vaccine Carrier and Improves the Immune Response in Mice". PLOS ONE.
- (March 2008). "Adenovirus vector induced innate immune responses: impact upon efficacy and toxicity in gene therapy and vaccine applications". Virus Res..
- (October 2004). "Adenoviruses as vaccine vectors". Mol. Ther..
- (April 2006). "Vaccine-preventable adenoviral respiratory illness in US military recruits, 1999-2004". Vaccine.
- "Vaccine Trials For "Boot Camp Crud" May Help 20 Percent of Recruits".
- (July 2001). "Two fatal cases of adenovirus-related illness in previously healthy young adults--Illinois, 2000". MMWR Morb. Mortal. Wkly. Rep..
- Malarkey MA, Baylor NW. FDA approval letter dated 16 March 2011.
- (31 August 2016). "Safety evaluation of adenovirus type 4 and type 7 vaccine live, oral in military recruits". Vaccine.
- [https://web.archive.org/web/20190512181807/https://www.fda.gov/media/80211/download Package insert for Adenovirus Type 4 and Type 7 Vaccine, Live, Oral], fda.gov, accessed 9 July 2020
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