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Adenosylcobinamide-GDP ribazoletransferase

Enzyme

Summary

Enzyme

Field	Value
Name	Adenosylcobinamide-GDP ribazoletransferase
EC_number	2.7.8.26
CAS_number	137672-85-6

Adenosylcobinamide-GDP ribazoletransferase (, CobS, cobalamin synthase, cobalamin-5'-phosphate synthase, cobalamin (5'-phosphate) synthase) is an enzyme with systematic name adenosylcobinamide-GDP:alpha-ribazole ribazoletransferase. This enzyme catalyses the following chemical reaction

: (1) adenosylcobinamide-GDP + alpha-ribazole \rightleftharpoons GMP + adenosylcobalamin : (2) adenosylcobinamide-GDP + alpha-ribazole 5'-phosphate \rightleftharpoons GMP + adenosylcobalamin 5'-phosphate

This enzyme is part of the biosynthetic pathway to cobalamin (vitamin B12) in bacteria.

References

(October 1999). "In vitro synthesis of the nucleotide loop of cobalamin by Salmonella typhimurium enzymes". Proceedings of the National Academy of Sciences of the United States of America.
(August 2002). "The biosynthesis of adenosylcobalamin (vitamin B12)". Natural Product Reports.
(October 1991). "Genetic analysis, nucleotide sequence, and products of two Pseudomonas denitrificans cob genes encoding nicotinate-nucleotide: dimethylbenzimidazole phosphoribosyltransferase and cobalamin (5'-phosphate) synthase". Journal of Bacteriology.

Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

ec-2.7.8

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