From Surf Wiki (app.surf) — the open knowledge base
Adapalene/benzoyl peroxide
Pharmaceutical combination
Pharmaceutical combination
| Field | Value |
|---|---|
| Verifiedfields | changed |
| Watchedfields | changed |
| verifiedrevid | 448240024 |
| type | combo |
| image | Adapalene and benzoyl peroxide.svg |
| image_class | skin-invert-image |
| component1 | Adapalene |
| class1 | Retinoid |
| component2 | Benzoyl peroxide |
| class2 | Peroxide |
| tradename | Epiduo, Epiduo Forte, Tactupump Forte, Desarena, Effezel, Belakne Combi, Aciduo |
| Drugs.com | |
| DailyMedID | Adapalene and benzoyl peroxide |
| pregnancy_AU | |
| routes_of_administration | Topical |
| ATC_prefix | D10 |
| ATC_suffix | AD53 |
| ATC_supplemental | |
| legal_AU | S4 |
| legal_AU_comment | |
| legal_BR | |
| legal_CA | |
| legal_DE | |
| legal_NZ | |
| legal_UK | |
| legal_US | Rx-only |
| legal_US_comment | |
| legal_UN | |
| legal_status | Rx-only |
| CAS_number_Ref | |
| CAS_number | 1194805-81-6 |
| KEGG_Ref | |
| KEGG | D10792 |
| Drugs.com =
Adapalene/benzoyl peroxide, sold under the brand name Epiduo among others, is a fixed-dose combination medication for the treatment of acne vulgaris. It is a combination of adapalene, a retinoid; and benzoyl peroxide.
It is available as a generic medication. In 2023, it was the 319th most commonly prescribed medication in the United States, with more than 200,000 prescriptions.
Medical uses
Adapalene/benzoyl peroxide is indicated for the topical treatment of acne vulgaris.
Side effects
Commonly reported side effects include the following:
- Skin redness
- Scaling
- Dry skin
- Contact dermatitis
- Skin irritation
- Stinging
- Burning
Research
A 2011 meta-analysis of clinical trials has shown this combined therapy to be more effective than either of its ingredients by themselves.
The use of adapalene/benzoyl peroxide in combination with oral antibiotics (lymecycline) has been studied; the combination was well tolerated and showed an improved success rate compared to those receiving only antibiotics (47.6% vs. 33.7%, P = 0.002).
References
References
- (16 April 2025). "Adapax (Nova Pharmaceuticals Australasia Pty Ltd)".
- (21 February 2018). "Epiduo- adapalene and benzoyl peroxide gel".
- (27 April 2022). "Epiduo Forte- adapalene and benzoyl peroxide gel".
- (29 June 2023). "Competitive Generic Therapy Approvals".
- "Adapalene; Benzoyl Peroxide Drug Usage Statistics, United States, 2013 - 2022".
- (August 2011). "Synergistic efficacy of adapalene 0.1%-benzoyl peroxide 2.5% in the treatment of 3855 acne vulgaris patients". The Journal of Dermatological Treatment.
- (August 2011). "Combination therapy with adapalene-benzoyl peroxide and oral lymecycline in the treatment of moderate to severe acne vulgaris: a multicentre, randomized, double-blind controlled study". The British Journal of Dermatology.
This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.
Ask Mako anything about Adapalene/benzoyl peroxide — get instant answers, deeper analysis, and related topics.
Research with MakoFree with your Surf account
Create a free account to save articles, ask Mako questions, and organize your research.
Sign up freeThis content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.
Report