Aaron Klug

Early life and education

Klug was born in Želva, in Lithuania, to Jewish parents Lazar, a cattleman, and Bella (née Silin) Klug, with whom he emigrated to South Africa at the age of two. He was educated at Durban High School. Paul de Kruif's 1926 book, * Microbe Hunters*, aroused his interest in microbiology.

Klug was part of the Hashomer Hatzair Jewish Zionist youth movement in South Africa.

He started to study microbiology, but then moved into physics and maths, graduating with a Bachelor of Science degree at the University of the Witwatersrand, in Johannesburg. He studied physics under Reginald W. James and obtained his Master of Science degree at the University of Cape Town. He was awarded an 1851 Research Fellowship from the Royal Commission for the Exhibition of 1851, which enabled him to move to England, completing his PhD in research physics at Trinity College, Cambridge in 1953.

Career and research

Following his PhD, Klug moved to Birkbeck College in the University of London in late 1953, and started working with chemist and X-ray crystallographer Rosalind Franklin in the lab of crystallographer John Bernal. This experience aroused a lifelong interest in the study of viruses, and during his time there he made discoveries in the structure of the tobacco mosaic virus. In 1962 he moved to the newly built Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) in Cambridge. Over the following decade Klug used methods from X-ray diffraction, microscopy and structural modelling to develop crystallographic electron microscopy in which a sequence of two-dimensional images of crystals taken from different angles are combined to produce three-dimensional images of the target. He studied the structure of transfer RNA, and found what is known as zinc fingers as well as the neurofibrils in Alzheimer's disease.

Also in 1962, Klug became a Fellow of Peterhouse, Cambridge. He was later made an Honorary Fellow of the college.

Between 1986 and 1996, Klug was director of the LMB. He served on the Advisory Council for the Campaign for Science and Engineering. He also served on the Board of Scientific Governors at The Scripps Research Institute. He and Dai Rees approached the Wellcome Trust to found the Wellcome Sanger Institute, which was a key player in the Human Genome Project.

Awards and honours

Klug was awarded the Louisa Gross Horwitz Prize from Columbia University in 1981. He was knighted by Elizabeth II in 1988. In 1969 he was elected a Fellow of the Royal Society (FRS), the oldest national scientific institution in the world. He was elected its President (PRS) from 1995 to 2000. He was appointed to the Order of Merit in 1995 – as is customary for Presidents of the Royal Society. His certificate of election to the Royal Society reads:

Klug was a member of the American Academy of Arts and Sciences and the American Philosophical Society

In 2000, Klug received the Golden Plate Award of the American Academy of Achievement. In 2005, he was awarded South Africa's Order of Mapungubwe (gold) for exceptional achievements in medical science. He was elected a Fellow of the Academy of Medical Sciences (FMedSci), also in 2005.

In 2013, Israel's Ben-Gurion University of the Negev dedicated their centre for structural biology in Klug's name, Aaron Klug Integrated Centre for Biomolecular Structure. He, his family and the then-British Ambassador to Israel Matthew Gould, were in attendance. Klug was associated with the university and the town of Be'er Sheva, having visited them numerous times.

Personal life

Klug married Liebe Bobrow in 1948;

Though Klug had faced discrimination in South Africa, he remained religious and according to Sydney Brenner, he became more religious in his older age.

References

References

1. {{MathGenealogy
2. Shur, Chaim. (1998). "Shomrim in the land of Apartheid : the story of Hashomer Hatzair in South Africa 1935–1970". Members of Hashomer Hatzair South Africa and Havazelet in conjunction with Yad Yaari.
3. Anon. (2015). "Klug, Sir Aaron".
4. Klug, Aaron. (1953). "The kinetics of phase changes in solids.". University of Cambridge.
5. (2004). "Aaron Klug and the revolution in biomolecular structure determination". Trends in Cell Biology.
6. (2018). "Aaron Klug". The Lancet.
7. "Advisory Council of the Campaign for Science and Engineering". Sciencecampaign.org.uk.
8. (26 January 2004). "Scripps Research Scientific Board Meets in Florida". [[Scripps Research Institute]].
9. "Aaron Klug (1926–)". Jewish Virtual Library.
10. "Sir Aaron Klug OM FRS". [[Royal Society]].
11. ["Certificate of Election EC/1969/19: Aaron Klug"](https://collections.royalsociety.org/DServe.exe?dsqIni=Dserve.ini&dsqApp=Archive&dsqDb=Catalog&dsqCmd=show.tcl&dsqSearch=(RefNo==%27EC%2F1969%2F19%27). [[Royal Society]].
12. "Aaron Klug".
13. "APS Member History".
14. "Golden Plate Awardees of the American Academy of Achievement". [[American Academy of Achievement]].
15. (29 September 2005). "National Orders awards 27 September 2005". State of South Africa.
16. "Sir Aaron Klug – The Academy of Medical Sciences".
17. (14 April 2013). "Aaron Klug Integrated Centre for Biomolecular Structure and Function Dedicated".
18. (26 November 2018). "Sir Aaron Klug obituary".
19. Rhodes, D.. (2019). "Aaron Klug (1926–2018)". Nat Struct Mol Biol.
20. Hargittai, Istva'n & Magdolna. 2006. ''Candid Science VI: More Conversations with Famous Scientists''. Imperial College Press, p. 33