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7,12-Dimethylbenz(a)anthracene

7,12-Dimethylbenzanthracene 7,12-Dimethyltetraphene 1,4-Dimethyl-2,3-benzophenanthrene | NFPA-H = 2 | NFPA-R = 0 | NFPA-F = 0 | NFPA-S =

7,12-Dimethylbenz[a]anthracene (DMBA) is an immunosuppressor and a powerful organ-specific laboratory carcinogen. DMBA is widely used in many research laboratories studying cancer. DMBA serves as a tumor initiator. Tumor promotion can be induced with treatments of 12-O-tetradecanoylphorbol-13-acetate (TPA) in some models of two-stage carcinogenesis. This allows for a greatly accelerated rate of tumor growth, making many cancer studies possible.

References

References

  1. [http://www.sigmaaldrich.com/catalog/search/ProductDetail/SIGMA/D3254 7,12-Dimethylbenz(a)anthracene] at [[Sigma-Aldrich]]
  2. Miyata M. (2001). "Mechanism of 7, 12-Dimethylbenz[a]anthracene-Induced Immunotoxicity: Role of Metabolic Activation at the Target Organ". Jpn J Pharmacol.
  3. Sung YM. (2005). "Lack of Expression of the EP2 but not EP3 Receptor for Prostaglandin E2 Results in Suppression of Skin Tumor Development". Cancer Res.
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polycyclic-aromatic-hydrocarbons carcinogens anthracenes immunosuppressants
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