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6-Hydroxy-3-succinoylpyridine 3-monooxygenase

Class of enzymes

Class of enzymes

FieldValue
Name6-hydroxy-3-succinoylpyridine 3-monooxygenase
EC_number1.14.13.163

6-hydroxy-3-succinoylpyridine 3-monooxygenase (, 6-hydroxy-3-succinoylpyridine hydroxylase, hspA (gene), hspB (gene)) is an enzyme with systematic name 4-(6-hydroxypyridin-3-yl)-4-oxobutanoate,NADH:oxygen oxidoreductase (3-hydroxylating, succinate semialdehyde releasing). This enzyme catalyses the following chemical reaction

: 4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 NADH + 2 H+ + O2 \rightleftharpoons 2,5-dihydroxypyridine + succinate semialdehyde + 2 NAD+ + H2O

6-hydroxy-3-succinoylpyridine 3-monooxygenase catalyses a reaction in the nicotine degradation pathway of Pseudomonas species.

References

References

  1. (March 2008). "A novel gene, encoding 6-hydroxy-3-succinoylpyridine hydroxylase, involved in nicotine degradation by Pseudomonas putida strain S16". Applied and Environmental Microbiology.
  2. (November 2011). "A novel NADH-dependent and FAD-containing hydroxylase is crucial for nicotine degradation by Pseudomonas putida". The Journal of Biological Chemistry.
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ec-1.14.13
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