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6-Fluoronorepinephrine

Chemical compound

Summary

Chemical compound

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6-Fluoronorepinephrine (6-FNE) is a selective α1- and α2-adrenergic receptor full agonist related to norepinephrine. It is the only selective full agonist for the α-adrenergic receptors known to date and has been used to study their function in scientific research. Infusion of 6-FNE into the locus coeruleus of rodents produces marked hyperactivity and behavioral disinhibition by suppressing activity in the area via stimulation of α1-adrenergic receptors.

References

(1979). "Synthesis and biological properties of 2-, 5-, and 6-fluoronorepinephrines". Journal of Medicinal Chemistry.
(2009). "Marked behavioral activation from inhibitory stimulation of locus coeruleus α₁-adrenoceptors by a full agonist". Brain Research.
(2003). "Role of epinephrine stimulation of CNS α₁-adrenoceptors in motor activity in mice". Synapse.

Wikipedia Source

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alpha1-adrenergic-agonists alpha2-adrenergic-agonists catecholamines fluorobenzene-derivatives phenylethanolamines

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