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5-hydroxyfuranocoumarin 5-O-methyltransferase

Class of enzymes

Summary

Class of enzymes

Field	Value
Name	5-hydroxyfuranocoumarin 5-O-methyltransferase
EC_number	2.1.1.69
CAS_number	67339-12-2, 101637-31-4

5-hydroxyfuranocoumarin 5-O-methyltransferase (, furanocoumarin 5-methyltransferase, furanocoumarin 5-O-methyltransferase, bergaptol 5-O-methyltransferase, bergaptol O-methyltransferase, bergaptol methyltransferase, S-adenosyl-L-methionine:bergaptol O-methyltransferase, BMT, S-adenosyl-L-methionine:5-hydroxyfuranocoumarin 5.1-O-methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:5-hydroxyfurocoumarin 5-O-methyltransferase. This enzyme catalyses the following chemical reaction

: (1) S-adenosyl-L-methionine + a 5-hydroxyfurocoumarin \rightleftharpoons S-adenosyl-L-homocysteine + a 5-methoxyfurocoumarin (general reaction) : (2) S-adenosyl-L-methionine + bergaptol \rightleftharpoons S-adenosyl-L-homocysteine + bergapten

The enzyme methylates the 5-hydroxy group of some hydroxy- and methylcoumarins, such as 5-hydroxyxanthotoxin.

References

(June 1978). "O-methyltransferases of furanocoumarin biosynthesis". Archives of Biochemistry and Biophysics.
(1979). "Separation of the S-adenosylmethionine: 5- and 8-hydroxyfuranocoumarin O-methyltransferases of Ruta graveolens L. by general ligand affinity chromatography". Zeitschrift für Naturforschung C.
(1986). "Elicitor-stimulated furanocoumarin biosynthesis in cultured parsley cells - ''S''-adenosyl-L-methionine-bergaptol and ''S''-adenosyl-L-methionine-xanthotoxol ''O''-methyltransferases". Zeitschrift für Naturforschung C.
(March 2004). "Furanocoumarin biosynthesis in Ammi majus L. Cloning of bergaptol O-methyltransferase". European Journal of Biochemistry.

Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

ec-2.1.1 coumarins-metabolism o-methylated-phenylpropanoids-metabolism

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