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5,6-dimethylbenzimidazole synthase
Class of enzymes
Class of enzymes
| Field | Value |
|---|---|
| Name | 5,6-dimethylbenzimidazole synthase |
| EC_number | 1.14.99.40 |
5,6-dimethylbenzimidazole synthase (, BluB) is an enzyme with systematic name FMNH2 oxidoreductase (5,6-dimethylbenzimidazole forming). This enzyme catalyses the following chemical reaction
: FMNH2 + NADH + H+ + O2 \rightleftharpoons 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + NAD+ + other product
The C-2 of 5,6-dimethylbenzimidazole is derived from C-1' of the ribityl group of FMNH2 and 2-H from the ribityl 1'-pro-S hydrogen. This enzyme is part of the biosynthetic pathway to cobalamin (vitamin B12) in bacteria.
References
References
- (February 2007). "Single-enzyme conversion of FMNH2 to 5,6-dimethylbenzimidazole, the lower ligand of B12". Proceedings of the National Academy of Sciences of the United States of America.
- (March 2007). "Biochemistry: molecular cannibalism". Nature.
- (March 2007). "BluB cannibalizes flavin to form the lower ligand of vitamin B12". Nature.
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