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4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase

Class of enzymes

Field	Value
Name	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase
EC_number	1.17.7.1
GO_code	0046429

In enzymology, a 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (HMB-PP synthase, IspG, ) is an enzyme that catalyzes the chemical reaction

:2-C-methyl-D-erythritol 2,4-cyclodiphosphate + protein-dithiol \rightleftharpoons (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + protein-disulfide

The substrate of this enzyme is 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEcPP) and the product is (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate (HMB-PP). Electrons are donated by two reduced ferredoxin proteins per reaction.

This enzyme participates in the MEP pathway (non-mevalonate pathway) of Isoprenoid precursor biosynthesis.

Nomenclature

This enzyme belongs to the family of oxidoreductases, specifically those acting on CH or CH2 groups with a disulfide as acceptor. The systematic name of this enzyme class is (E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:protein-disulfide oxidoreductase (hydrating).

References

Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

ec-1.17.7 enzymes-of-unknown-structure

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