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general/4-methoxyphenyl-compounds

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4-Bromoanisole

4-Bromoanisole is the organobromine compound with the formula CH3OC6H4Br. It is colorless liquid with a pleasant smell similar to that of anise seed. It is one of three isomers of bromoanisole, the others being 3-bromoanisole and 2-bromoanisole. It is the precursor to many 4-anisyl derivatives.

Reactions and uses

4-Bromoanisole forms a Grignard reagent,{{cite journal|doi=10.15227/orgsyn.071.0097|title=4-Methoxy-4'-Nitrobiphenyl|journal=Organic Syntheses|year=1993|volume=71|page=97|first1=J. K.|last1=Stille|first2=Antonio M. |last2=Echavarren|first3=Robert M.|last3=Williams|first4=James A.|last4=Hendrix : 3 CH3OC6H4MgBr + PCl3 → (CH3OC6H4)3P + 3 MgBrCl 4-Bromoanisole forms the organozinc derivative CH3OC6H4ZnBr.

4-Bromoanisole is compound sometimes used in RNA extraction which serves to further eliminate DNA contamination. It interacts with genomic DNA (gDNA) and through a separation phase, it will be located in the organic layer instead of the aqueous layer (upper layer) containing the RNA extract.

References

References

  1. (2012). "Multicomponent Synthesis of Tertiary Diarylmethylamines: 1-((4-Fluorophenyl)(4-methoxyphenyl)methyl)piperidine". Organic Syntheses.
  2. (March 2017). "NAzol RT".
  3. (2014). "Isolation of Small Noncoding RNAs from Human Serum". Journal of Visualized Experiments.
Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

4-methoxyphenyl-compounds 4-bromophenyl-compounds
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