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general/4-methoxyphenyl-compounds

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4-Bromoanisole

4-Bromoanisole is the organobromine compound with the formula CH3OC6H4Br. It is colorless liquid with a pleasant smell similar to that of anise seed. It is one of three isomers of bromoanisole, the others being 3-bromoanisole and 2-bromoanisole. It is the precursor to many 4-anisyl derivatives.

Reactions and uses

4-Bromoanisole forms a Grignard reagent,{{cite journal|doi=10.15227/orgsyn.071.0097|title=4-Methoxy-4'-Nitrobiphenyl|journal=Organic Syntheses|year=1993|volume=71|page=97|first1=J. K.|last1=Stille|first2=Antonio M. |last2=Echavarren|first3=Robert M.|last3=Williams|first4=James A.|last4=Hendrix : 3 CH3OC6H4MgBr + PCl3 → (CH3OC6H4)3P + 3 MgBrCl 4-Bromoanisole forms the organozinc derivative CH3OC6H4ZnBr.

4-Bromoanisole is compound sometimes used in RNA extraction which serves to further eliminate DNA contamination. It interacts with genomic DNA (gDNA) and through a separation phase, it will be located in the organic layer instead of the aqueous layer (upper layer) containing the RNA extract.

References

References

  1. (2012). "Multicomponent Synthesis of Tertiary Diarylmethylamines: 1-((4-Fluorophenyl)(4-methoxyphenyl)methyl)piperidine". Organic Syntheses.
  2. (March 2017). "NAzol RT".
  3. (2014). "Isolation of Small Noncoding RNAs from Human Serum". Journal of Visualized Experiments.
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