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3-Ketosteroid 9alpha-monooxygenase

Class of enzymes

Summary

Class of enzymes

FieldValue
Name3-ketosteroid 9alpha-monooxygenase
EC_number1.14.13.142

3-ketosteroid 9alpha-monooxygenase (, KshAB, 3-ketosteroid 9alpha-hydroxylase) is an enzyme with systematic name androsta-1,4-diene-3,17-dione,NADH:oxygen oxidoreductase (9alpha-hydroxylating). This enzyme catalyses the following chemical reaction

: androsta-1,4-diene-3,17-dione + NADH + H+ + O2 \rightleftharpoons 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + NAD+ + H2O

3-Ketosteroid 9alpha-monooxygenase is involved in the cholesterol degradation in several bacterial pathogens.

References

References

  1. (August 2009). "Rhodococcus rhodochrous DSM 43269 3-ketosteroid 9alpha-hydroxylase, a two-component iron-sulfur-containing monooxygenase with subtle steroid substrate specificity". Applied and Environmental Microbiology.
  2. (April 2009). "Characterization of 3-ketosteroid 9{alpha}-hydroxylase, a Rieske oxygenase in the cholesterol degradation pathway of Mycobacterium tuberculosis". The Journal of Biological Chemistry.
  3. (November 2011). "Activity of 3-ketosteroid 9α-hydroxylase (KshAB) indicates cholesterol side chain and ring degradation occur simultaneously in Mycobacterium tuberculosis". The Journal of Biological Chemistry.
Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

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