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3-deoxy-D-manno-octulosonic acid kinase

Class of enzymes

Class of enzymes

FieldValue
Name3-deoxy-D-manno-octulosonic acid kinase
EC_number2.7.1.166

3-deoxy-D-manno-octulosonic acid kinase (, kdkA (gene), Kdo kinase) is an enzyme with systematic name ATP:(KDO)-lipid IVA 3-deoxy-alpha-D-manno-oct-2-ulopyranose 4-phosphotransferase. This enzyme catalyses the following chemical reaction

: alpha-Kdo-(2-6)-lipid IVA + ATP \rightleftharpoons 4-O-phospho-alpha-Kdo-(2-6)-lipid IVA + ADP

The enzyme phosphorylates the 4-OH position of KDO in (KDO)-lipid IVA.

References

References

  1. (November 2000). "3-Deoxy-D-manno-oct-2-ulosonic acid (Kdo) transferase (WaaA) and kdo kinase (KdkA) of Haemophilus influenzae are both required to complement a waaA knockout mutation of Escherichia coli". The Journal of Biological Chemistry.
  2. (August 2007). "Pasteurella multocida expresses two lipopolysaccharide glycoforms simultaneously, but only a single form is required for virulence: identification of two acceptor-specific heptosyl I transferases". Infection and Immunity.
  3. (June 1997). "A mono-functional 3-deoxy-D-manno-octulosonic acid (Kdo) transferase and a Kdo kinase in extracts of Haemophilus influenzae". The Journal of Biological Chemistry.
  4. (October 1999). "A Haemophilus influenzae gene that encodes a membrane bound 3-deoxy-D-manno-octulosonic acid (Kdo) kinase. Possible involvement of kdo phosphorylation in bacterial virulence". The Journal of Biological Chemistry.
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