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3-Chlorophenmetrazine
3-Chlorophenmetrazine (3-CPM; code name PAL-594) is a recreational designer drug with stimulant effects. It is a substituted phenylmorpholine derivative, closely related to better known drugs such as phenmetrazine and 3-fluorophenmetrazine (3-FPM; PAL-593).
| Column 1 |
|---|
| 3-CPM; PAL-594; PAL594 |
| IUPAC name |
| 3-methyl-2-(3-chlorophenyl)morpholine |
| .mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}1097796-78-5 Y |
| 43350791 |
| 27935393 |
| B6P88Q2VW5 |
| DTXSID701337061 |
| C11H14ClNO |
| 211.69 g·mol−1 |
| Interactive image |
| SMILES |
| CC1C(OCCN1)C2=CC(=CC=C2)Cl |
| InChI |
| InChI=1S/C11H14ClNO/c1-8-11(14-6-5-13-8)9-3-2-4-10(12)7-9/h2-4,7-8,11,13H,5-6H2,1H3Key:BOFUZZAQNVYZFF-UHFFFAOYSA-N |
3-Chlorophenmetrazine (3-CPM; code name PAL-594) is a recreational designer drug with stimulant effects. It is a substituted phenylmorpholine derivative, closely related to better known drugs such as phenmetrazine and 3-fluorophenmetrazine (3-FPM; PAL-593).
The drug has been shown to act as a norepinephrine–dopamine releasing agent (NDRA) with additional weak serotonin release. Its EC50Tooltip half-maximal effective concentration values for induction of monoamine release are 27 nM for dopamine, 75 nM for norepinephrine, and 301 nM for serotonin in rat brain synaptosomes. Hence, it releases dopamine about 3-fold more potently than norepinephrine and about 11-fold more potently than serotonin.
Similarly to cis-4-methylaminorex, the drug is notable in being one of the most selective dopamine releasing agents (DRAs) known, although it still has substantial capacity to release norepinephrine.
- 3-Bromomethylphenidate
- 3-Chloromethamphetamine
- 3-Chloromethcathinone
- 4-Methylphenmetrazine
- G-130
- Methylenedioxyphenmetrazine
- Phendimetrazine
- PDM-35
- Radafaxine
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