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3,5,7-Trioxododecanoyl-CoA synthase

Class of enzymes

Summary

Class of enzymes

FieldValue
Name3,5,7-Trioxododecanoyl-CoA synthase
EC_number2.3.1.206

3,5,7-Trioxododecanoyl-CoA synthase (, TKS) is an enzyme with systematic name malonyl-CoA:hexanoyl-CoA malonyltransferase (3,5,7-trioxododecanoyl-CoA-forming). This enzyme catalyses the following chemical reaction

: 3 malonyl-CoA + hexanoyl-CoA \rightleftharpoons 3 CoA + 3,5,7-trioxododecanoyl-CoA + 3 CO2

This polyketide synthase catalyse the first step in the cannabinoids biosynthetic pathway of the plant Cannabis sativa.

References

References

  1. (June 2009). "Characterization of olivetol synthase, a polyketide synthase putatively involved in cannabinoid biosynthetic pathway". FEBS Letters.
  2. (July 2012). "Identification of olivetolic acid cyclase from Cannabis sativa reveals a unique catalytic route to plant polyketides". Proceedings of the National Academy of Sciences of the United States of America.
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ec-2.3.1
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