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27S pre-rRNA (guanosine2922-2'-O)-methyltransferase

Class of enzymes

Summary

Class of enzymes

Field	Value
Name	27S pre-rRNA (guanosine2922-2'-O)-methyltransferase
EC_number	2.1.1.167

27S pre-rRNA (guanosine2922-2'-O)-methyltransferase (, Spb1p (gene), YCL054W (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:27S pre-rRNA (guanosine2922-2'-O-)-methyltransferase. This enzyme catalyses the following chemical reaction

: S-adenosyl-L-methionine + guanosine2922 in 27S pre-rRNA \rightleftharpoons S-adenosyl-L-homocysteine + 2'-O-methylguanosine2922 in 27S pre-rRNA

Spb1p is a site-specific 2'-O-ribose RNA methyltransferase that catalyses the formation of 2'-O-methylguanosine2922.

References

(November 2004). "Spb1p-directed formation of Gm2922 in the ribosome catalytic center occurs at a late processing stage". Molecular Cell.
(November 2003). "Functional redundancy of Spb1p and a snR52-dependent mechanism for the 2'-O-ribose methylation of a conserved rRNA position in yeast". Molecular Cell.

Wikipedia Source

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ec-2.1.1

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