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23S rRNA (uracil1939-C5)-methyltransferase

Class of enzymes

Class of enzymes

FieldValue
Name23S rRNA (uracil1939-C5)-methyltransferase
EC_number2.1.1.190

23S rRNA (uracil1939-C5)-methyltransferase (, RumA, RNA uridine methyltransferase A, YgcA) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (uracil1939-C5)-methyltransferase. This enzyme catalyses the following chemical reaction

: S-adenosyl-L-methionine + uracil1939 in 23S rRNA \rightleftharpoons S-adenosyl-L-homocysteine + 5-methyluracil1939 in 23S rRNA

The enzyme specifically methylates uracil1939 at C5 in 23S rRNA.

References

References

  1. (March 2002). "Characterization of the 23 S ribosomal RNA m5U1939 methyltransferase from Escherichia coli". The Journal of Biological Chemistry.
  2. (March 2004). "Crystal structure of RumA, an iron-sulfur cluster containing E. coli ribosomal RNA 5-methyluridine methyltransferase". Structure.
  3. (August 2003). "Identifying the methyltransferases for m(5)U747 and m(5)U1939 in 23S rRNA using MALDI mass spectrometry". Nucleic Acids Research.
  4. (February 2010). "Mutagenesis of the modified bases, m(5)U1939 and psi2504, in Escherichia coli 23S rRNA". Biochemical and Biophysical Research Communications.
  5. (August 2004). "Redox reactions of the iron-sulfur cluster in a ribosomal RNA methyltransferase, RumA: optical and EPR studies". The Journal of Biological Chemistry.
  6. (March 2005). "A unique RNA Fold in the RumA-RNA-cofactor ternary complex contributes to substrate selectivity and enzymatic function". Cell.
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