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23S rRNA (guanine748-N1)-methyltransferase

Class of enzymes

Class of enzymes

FieldValue
Name23S rRNA (guanine748-N1)-methyltransferase
EC_number2.1.1.188

23S rRNA (guanine748-N1)-methyltransferase (, Rlma(II), Rlma2, 23S rRNA m1G748 methyltransferase, RlmaII, Rlma II, tylosin-resistance methyltransferase RlmA(II), TlrB, rRNA large subunit methyltransferase II) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (guanine748-N1)-methyltransferase. This enzyme catalyses the following chemical reaction

: S-adenosyl-L-methionine + guanine748 in 23S rRNA \rightleftharpoons S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA

The enzyme specifically methylates guanine748 at N1 in 23S rRNA.

References

References

  1. (April 2004). "The tylosin-resistance methyltransferase RlmA(II) (TlrB) modifies the N-1 position of 23S rRNA nucleotide G748". Journal of Molecular Biology.
  2. (August 2000). "The tylosin resistance gene tlrB of Streptomyces fradiae encodes a methyltransferase that targets G748 in 23S rRNA". Molecular Microbiology.
  3. (January 2003). "Structure of 23S rRNA hairpin 35 and its interaction with the tylosin-resistance methyltransferase RlmAII". The EMBO Journal.
  4. (September 2007). "Recognition elements in rRNA for the tylosin resistance methyltransferase RlmA(II)". Journal of Molecular Biology.
  5. (May 2008). "Interaction of the tylosin-resistance methyltransferase RlmA II at its rRNA target differs from the orthologue RlmA I". Journal of Molecular Biology.
  6. (April 2002). "Methylation at nucleotide G745 or G748 in 23S rRNA distinguishes Gram-negative from Gram-positive bacteria". Molecular Microbiology.
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