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23S rRNA (guanine745-N1)-methyltransferase

Class of enzymes

Class of enzymes

FieldValue
Name23S rRNA (guanine745-N1)-methyltransferase
EC_number2.1.1.187

23S rRNA (guanine745-N1)-methyltransferase (, Rlma(I), Rlma1, 23S rRNA m1G745 methyltransferase, YebH, RlmAI methyltransferase, ribosomal RNA(m1G)-methylase, rRNA(m1G)methylase, RrmA, 23S rRNA:m1G745 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (guanine745-N1)-methyltransferase. This enzyme catalyses the following chemical reaction

: S-adenosyl-L-methionine + guanine745 in 23S rRNA \rightleftharpoons S-adenosyl-L-homocysteine + N1-methylguanine745 in 23S rRNA

The enzyme specifically methylates guanine745 at N1 in 23S rRNA.

References

References

  1. (November 2004). "Methylation of 23S rRNA nucleotide G745 is a secondary function of the RlmAI methyltransferase". RNA.
  2. (January 1998). "Identification of the rrmA gene encoding the 23S rRNA m1G745 methyltransferase in Escherichia coli and characterization of an m1G745-deficient mutant". Journal of Bacteriology.
  3. (March 2004). "Crystal structure of RlmAI: implications for understanding the 23S rRNA G745/G748-methylation at the macrolide antibiotic-binding site". Proceedings of the National Academy of Sciences of the United States of America.
  4. (July 2001). "Recognition of nucleotide G745 in 23 S ribosomal RNA by the rrmA methyltransferase". Journal of Molecular Biology.
  5. (April 2002). "Methylation at nucleotide G745 or G748 in 23S rRNA distinguishes Gram-negative from Gram-positive bacteria". Molecular Microbiology.
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