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23S rRNA (guanine2535-N1)-methyltransferase

Class of enzymes

Class of enzymes

FieldValue
Name23S rRNA (guanine2535-N1)-methyltransferase
EC_number2.1.1.209

23S rRNA (guanine2535-N1)-methyltransferase (, AviRa) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (guanine2535-N1)-methyltransferase. This enzyme catalyses the following chemical reaction

: S-adenosyl-L-methionine + guanine2535 in 23S rRNA \rightleftharpoons S-adenosyl-L-homocysteine + N1-methylguanine2535 in 23S rRNA

This is one of the methyltransferases from Streptomyces viridochromogenes . Streptomyces viridochromogenes produces the antibiotic avilamycin A which binds to the 50S ribosomal subunit to inhibit protein synthesis.

References

References

  1. (July 2003). "The avilamycin resistance determinants AviRa and AviRb methylate 23S rRNA at the guanosine 2535 base and the uridine 2479 ribose". Molecular Microbiology.
  2. (March 2001). "An ATP-binding cassette transporter and two rRNA methyltransferases are involved in resistance to avilamycin in the producer organism Streptomyces viridochromogenes Tü57". Antimicrobial Agents and Chemotherapy.
  3. (May 2003). "Crystal structure of the avilamycin resistance-conferring methyltransferase AviRa from Streptomyces viridochromogenes". Journal of Molecular Biology.
  4. (November 2016). "Avilamycin and evernimicin induce structural changes in rProteins uL16 and CTC that enhance the inhibition of A-site tRNA binding". Proceedings of the National Academy of Sciences of the United States of America.
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