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23S rRNA (adenine2503-C8)-methyltransferase

Class of enzymes

Class of enzymes

FieldValue
Name23S rRNA (adenine2503-C8)-methyltransferase
EC_number2.1.1.224

23S rRNA (adenine2503-C8)-methyltransferase (, Cfr (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (adenine2503-C8)-methyltransferase. This enzyme catalyses the following chemical reaction

: 2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA \rightleftharpoons S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA

This enzyme is a member of the 'AdoMet radical' (radical SAM) family.

References

References

  1. (February 2009). "Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteria". RNA.
  2. (March 2010). "Insights into the structure, function and evolution of the radical-SAM 23S rRNA methyltransferase Cfr that confers antibiotic resistance in bacteria". Nucleic Acids Research.
  3. (March 2010). "RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA". Journal of the American Chemical Society.
  4. (March 2011). "RNA methylation by radical SAM enzymes RlmN and Cfr proceeds via methylene transfer and hydride shift". Proceedings of the National Academy of Sciences of the United States of America.
  5. (April 2011). "A radically different mechanism for S-adenosylmethionine-dependent methyltransferases". Science.
  6. (May 2011). "Structural basis for methyl transfer by a radical SAM enzyme". Science.
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ec-2.1.1
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