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23S rRNA (adenine2503-C2)-methyltransferase

Class of enzymes

Class of enzymes

FieldValue
Name23S rRNA (adenine2503-C2)-methyltransferase
EC_number2.1.1.192

23S rRNA (adenine2503-C2)-methyltransferase (, RlmN, YfgB, Cfr) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (adenine2503-C2)-methyltransferase. This enzyme catalyses the following chemical reaction

: 2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA \rightleftharpoons S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA

23S rRNA (adenine2503-C2)-methyltransferase contains an [4Fe-4S] cluster.

References

References

  1. (January 2008). "The methyltransferase YfgB/RlmN is responsible for modification of adenosine 2503 in 23S rRNA". RNA.
  2. (March 2010). "RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA". Journal of the American Chemical Society.
  3. (March 2011). "RNA methylation by radical SAM enzymes RlmN and Cfr proceeds via methylene transfer and hydride shift". Proceedings of the National Academy of Sciences of the United States of America.
  4. (April 2011). "A radically different mechanism for S-adenosylmethionine-dependent methyltransferases". Science.
  5. (May 2011). "Structural basis for methyl transfer by a radical SAM enzyme". Science.
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