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23S rRNA (adenine2503-C2,C8)-dimethyltransferase

Obsolete enzyme family

Obsolete enzyme family

FieldValue
Name23S rRNA (adenine2503-C2,C8)-dimethyltransferase
EC_number2.1.1.194
CAS_number39369-30-7

**** (, Cfr, Cfr methyltransferase, Cfr rRNA methyltransferase) is an enzyme with systematic name . This enzyme catalyses the following chemical reaction

: 2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA \rightleftharpoons 2 S-adenosyl-L-homocysteine + 2,8-dimethyladenine2503 in 23S rRNA

This enzyme contains an [4Fe-S] cluster.

References

References

  1. (March 2010). "RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA". Journal of the American Chemical Society.
  2. (February 2009). "Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteria". RNA.
  3. (March 2010). "Insights into the structure, function and evolution of the radical-SAM 23S rRNA methyltransferase Cfr that confers antibiotic resistance in bacteria". Nucleic Acids Research.
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This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

ec-2.1.1
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