| Berkshire, Hampshire and Franklin | Andrea Nuciforo, Jr. (D-Pittsfield) | retired to run for Middle Berkshire Register of Deeds | Benjamin Downing (D-Pittsfield)* |
| Matthew W. Kinnaman (R-Lee) |
| Dion Robbins-Zust (G-Richmond) | 37,763 |
| 13,595 |
| 1,988 |
| Bristol and Norfolk | James Timility (D-Walpole) | sought re-election | James Timility (D-Walpole) |
| Michael Atwill (R-Mansfield) | 34,702 |
| 22,865 |
| 1st Bristol and Plymouth | Joan Menard (D-Somerset) | sought re-election | Joan Menard (D-Somerset) |
| Unopposed | 39,235 |
| 2nd Bristol and Plymouth | Mark Montigny (D-New Bedford) | sought re-election | Mark Montigny (D-New Bedford) |
| Raimundo Delgado (U-New Bedford) | 37,547 |
| 8,104 |
| Cape and Islands | Robert O'Leary (D-Barnstable) | sought re-election | Robert O'Leary (D-Barnstable) |
| Ricardo Barros (R-Centerville)* | 48,212 |
| 27,918 |
| 1st Essex | Steven Baddour (D-Methuen) | sought re-election | Steven Baddour (D-Methuen) |
| Unopposed | 43,437 |
| 2nd Essex | Frederick Berry (D-Peabody) | sought re-election | Frederick Berry (D-Peabody) |
| Unopposed | 48,662 |
| 1st Essex and Middlesex | Bruce Tarr (R-Gloucester) | sought re-election | Bruce Tarr (R-Gloucester) |
| Unopposed | 56,605 |
| 2nd Essex and Middlesex | Susan Tucker (D-Andover) | sought re-election | Susan Tucker (D-Andover) |
| Unopposed | 35,991 |
| 3rd Essex and Middlesex | Thomas M. McGee (D-Lynn) | sought re-election | Thomas M. McGee (D-Lynn) |
| Unopposed | 38,229 |
| Hampden | Stephen Buoniconti (D-West Springfield) | sought re-election | Stephen Buoniconti (D-West Springfield) |
| Unopposed | 29,515 |
| 1st Hampden and Hampshire | Brian Lees (R-East Longmeadow) | retired to run for Hampden County Clerk of Courts | Enrico John Villamaino III (R-East Longmeadow)* |
| Gale D. Candaras (D-Wilbraham)* | 20,465 |
| 30,366 |
| 2nd Hampden and Hampshire | Michael Knapik (R-Westfield) | sought re-election | Michael Knapik (R-Westfield) |
| Unopposed | 37,842 |
| Hampshire and Franklin | Stanley Rosenberg (D-Amherst) | sought re-election | Stanley Rosenberg (D-Amherst) |
| Michaela LeBlanc (R-Northampton) | 46,417 |
| 8,444 |
| 1st Middlesex | Steven Panagiotakos (D-Lowell) | sought re-election | Steven Panagiotakos (D-Lowell) |
| Brooks Lyman (R-Groton) | 32,403 |
| 10,314 |
| 2nd Middlesex | Pat Jehlan (D-Somerville) | sought re-election | Pat Jehlan (D-Somerville) |
| Unopposed | 38,780 |
| 3rd Middlesex | Susan Fargo (D-Lincoln) | sought re-election | Susan Fargo (D-Lincoln) |
| Sandra Martinez (R-Chelmsford) | 38,200 |
| 21,557 |
| 4th Middlesex* | Robert Havern III (D-Arlington) | sought re-election | Robert Havern III (D-Arlington)* |
| Unopposed | 47,947 |
| Middlesex and Essex | Richard Tisei (R-Wakefield) | sought re-election | Richard Tisei (R-Wakefield) |
| Unopposed | 43,466 |
| 1st Middlesex and Norfolk | Cynthia Stone Creem (D-Newton) | sought re-election | Cynthia Stone Creem (D-Newton) |
| Unopposed | 45,117 |
| 2nd Middlesex and Norfolk | Karen Spilka (D-Ashland) | sought re-election | Karen Spilka (D-Ashland) |
| Unopposed | 43,657 |
| Middlesex, Suffolk and Essex | Jarrett Barrios (D-Cambridge) | sought re-election | Jarrett Barrios (D-Cambridge) |
| Unopposed | 31,860 |
| Middlesex and Worcester | Pamela Resor (D-Acton) | sought re-election | Pamela Resor (D-Acton) |
| Unopposed | 49,747 |
| Norfolk, Bristol and Middlesex | Scott Brown (R-Wrentham) | sought re-election | Scott Brown (R-Wrentham) |
| Unopposed | 46,972 |
| Norfolk, Bristol and Plymouth | Brian Joyce (D-Milton) | sought re-election | Brian Joyce (D-Milton) |
| James Aldred (R-Randolph) | 43,811 |
| 14,327 |
| Norfolk and Plymouth | Michael W. Morrissey (D-Quincy) | sought re-election | Michael W. Morrissey (D-Quincy) |
| Unopposed | 42,747 |
| Plymouth and Barnstable | Therese Murray (D-Plymouth) | sought re-election | Therese Murray (D-Plymouth) |
| Unopposed | 54,042 |
| 1st Plymouth and Bristol | Marc Pacheco (D-Taunton) | sought re-election | Marc Pacheco (D-Taunton) |
| Unopposed | 43,200 |
| 2nd Plymouth and Bristol | Robert Creedon, Jr. (D-Brockton) | sought re-election | Robert Creedon, Jr. (D-Brockton) |
| Unopposed | 35,820 |
| Plymouth and Norfolk | Robert Hedlund (R-Weymouth) | sought re-election | Robert Hedlund (R-Weymouth) |
| Stephen Lynch (D-Marshfield)* | 43,638 |
| 24,114 |
| 1st Suffolk | John Hart, Jr. (D-Boston) | sought re-election | John Hart, Jr. (D-Boston) |
| Unopposed | 33,084 |
| 2nd Suffolk* | Dianne Wilkerson (D-Boston) | sought re-election | Dianne Wilkerson (D-Boston)* |
| Samiyah Diaz (R-Boston) | 28,820 |
| 11,079 |
| 1st Suffolk and Middlesex | Robert Travaglini (D-Boston) | sought re-election | Robert Travaglini (D-Boston) |
| Unopposed | 32,621 |
| 2nd Suffolk and Middlesex | Steven Tolman (D-Boston) | sought re-election | Steven Tolman (D-Boston) |
| Unopposed | 36,827 |
| Suffolk and Norfolk | Marian Walsh (D-Boston) | sought re-election | Marian Walsh (D-Boston) |
| Douglas Obey (R-Westwood) | 37,930 |
| 17,253 |
| 1st Worcester | Harriette Chandler (D-Worcester)* | sought re-election | Harriette Chandler (D-Worcester)* |
| Paul Nordborg (R-Holden) | 35,904 |
| 13,269 |
| 2nd Worcester | Edward Augustus, Jr. (D-Worcester) | sought re-election | Edward Augustus, Jr. (D-Worcester) |
| Richard Peters (R-Worcester) |
| John Lazzaro (I-Millbury) | 33,187 |
| 12,352 |
| 3,616 |
| Worcester, Hampden, Hampshire and Franklin | Stephen Brewer (D-Barre) | sought re-election | Stephen Brewer (D-Barre) |
| Unopposed | 48,460 |
| Worcester and Middlesex | Robert Antonioni (D-Leominster) | sought re-election | Robert Antonioni (D-Leominster) |
| Unopposed | 41,373 |
| Worcester and Norfolk | Richard T. Moore (D-Uxbridge) | sought re-election | Richard T. Moore (D-Uxbridge) |
| Unopposed | 44,702 |