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2-oxopropyl-CoM reductase (carboxylating)

Class of enzymes

Field	Value
Name	2-oxopropyl-CoM reductase (carboxylating)
EC_number	1.8.1.5
GO_code	0050628

In enzymology, a 2-oxopropyl-CoM reductase (carboxylating) () is an enzyme that catalyzes the chemical reaction

:2-mercaptoethanesulfonate + acetoacetate + NADP+ \rightleftharpoons 2-(2-oxopropylthio)ethanesulfonate + CO2 + NADPH

The 3 substrates of this enzyme are 2-mercaptoethanesulfonate, acetoacetate, and NADP+, whereas its 3 products are 2-(2-oxopropylthio)ethanesulfonate, CO2, and NADPH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-mercaptoethanesulfonate, acetoacetate:NADP+ oxidoreductase (decarboxylating). Other names in common use include NADPH:2-(2-ketopropylthio)ethanesulfonate, oxidoreductase/carboxylase, and NADPH:2-ketopropyl-coenzyme M oxidoreductase/carboxylase.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes and .

References

Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

ec-1.8.1 nadph-dependent-enzymes enzymes-of-known-structure

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