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18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase

Class of enzymes

Class of enzymes

FieldValue
Name18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase
EC_number2.1.1.183

18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase (, 18S rRNA dimethylase Dim1p, Dim1p, ScDim1, m2(6)A dimethylase, KIDIM1) is an enzyme with systematic name S-adenosyl-L-methionine:18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase. This enzyme catalyses the following chemical reaction

: 4 S-adenosyl-L-methionine + adenine1779/adenine1780 in 18S rRNA \rightleftharpoons 4 S-adenosyl-L-homocysteine + N6-dimethyladenine1779/N6-dimethyladenine1780 in 18S rRNA

DIM1 is involved in pre-rRNA processing.

References

References

  1. (October 1995). "The 18S rRNA dimethylase Dim1p is required for pre-ribosomal RNA processing in yeast". Genes & Development.
  2. (April 1998). "Yeast 18S rRNA dimethylase Dim1p: a quality control mechanism in ribosome synthesis?". Molecular and Cellular Biology.
  3. (September 2009). "Structural and functional divergence within the Dim1/KsgA family of rRNA methyltransferases". Journal of Molecular Biology.
  4. (August 1994). "The DIM1 gene responsible for the conserved m6(2)Am6(2)A dimethylation in the 3'-terminal loop of 18 S rRNA is essential in yeast". Journal of Molecular Biology.
  5. (May 2006). "Recognition of a complex substrate by the KsgA/Dim1 family of enzymes has been conserved throughout evolution". RNA.
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ec-2.1.1
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