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11-cis-retinol dehydrogenase

Class of enzymes

Field	Value
Name	11-cis-retinol dehydrogenase
EC_number	1.1.1.315

11-cis-retinol dehydrogenase (, RDH5 (gene)) is an enzyme with systematic name 11-cis-retinol:NAD+ oxidoreductase. This enzyme catalyses the following chemical reaction

: 11-cis-retinol---[retinal-binding-protein] + NAD+ \rightleftharpoons 11-cis-retinal---[retinol-binding-protein] + NADH + H+

11-cis-retinol

This enzyme from retinal pigment epithelium, catalyses the reduction of 11-cis-retinol to 11-cis-retinal.

References

(January 1995). "The retinal pigment epithelial-specific 11-cis retinol dehydrogenase belongs to the family of short chain alcohol dehydrogenases". The Journal of Biological Chemistry.
(February 1999). "Activity of human 11-cis-retinol dehydrogenase (Rdh5) with steroids and retinoids and expression of its mRNA in extra-ocular human tissue". The Biochemical Journal.
(December 2001). "Biochemical defects in 11-cis-retinol dehydrogenase mutants associated with fundus albipunctatus". The Journal of Biological Chemistry.
(April 2003). "Mapping the ligand binding pocket in the cellular retinaldehyde binding protein". The Journal of Biological Chemistry.

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ec-1.1.1

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