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1-phosphofructokinase

InterPro Family

Field	Value
Name	1-phosphofructokinase
EC_number	2.7.1.56
CAS_number	37278-03-8
GO_code	0008662
image	2abq.jpg
caption	Fructose 1-phosphate kinase homodimer, Bacillus halodurans

In enzymology, 1-phosphofructokinase () is an enzyme that catalyzes the chemical reaction

:ATP + D-fructose 1-phosphate → ADP + D-fructose 1,6-bisphosphate

Thus, the two substrates of this enzyme are ATP and D-fructose 1-phosphate, whereas its two products are ADP and D-fructose 1,6-bisphosphate. The enzyme was first described and characterized in the 1960s.

This enzyme belongs to the phosphofructokinase B (PfkB) or Ribokinase family of sugar kinases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:D-fructose-phosphate 6-phosphotransferase. Other names in common use include fructose-1-phosphate kinase, 1-phosphofructokinase (phosphorylating), D-fructose-1-phosphate kinase, fructose 1-phosphate kinase, and 1-phosphofructokinase. This enzyme participates in fructose and mannose metabolism. The members of the PfkB/RK family are identified by the presence of three conserved sequence motifs and their enzymatic activity generally shows a dependence on the presence of pentavalent ions.

Structure

As of 2021, two structures have been solved for this class of enzymes, with the PDB accession codes and , both from structural genomics efforts. The protein is a homodimer.

References

(1966). "1-Phosphofructokinase from an anaerobe". J. Biol. Chem..
(1969). "D-fructose 1-phosphate kinase and D-fructose 6-phosphate kinase from Aerobacter aerogenes. A comparative study of regulatory properties". J. Biol. Chem..
Park J, Gupta RS: Adenosine kinase and ribokinase--the RK family of proteins. Cell Mol Life Sci 2008, 65: 2875-2896.
Bork P, Sander C, Valencia A: Convergent evolution of similar enzymatic function on different protein folds: the hexokinase, ribokinase, and galactokinase families of sugar kinases. Protein Sci 1993, 2: 31-40.
Maj MC, Singh B, Gupta RS: Pentavalent ions dependency is a conserved property of adenosine kinase from diverse sources: identification of a novel motif implicated in phosphate and magnesium ion binding and substrate inhibition. Biochemistry 2002, 41: 4059-4069.

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ec-2.7.1 enzymes-of-known-structure

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