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1,8-Cineole 2-exo-monooxygenase

Class of enzymes

Class of enzymes

FieldValue
Name1,8-Cineole 2-exo-monooxygenase
EC_number1.14.13.157

1,8-Cineole 2-exo-monooxygenase (, CYP3A4) is an enzyme with systematic name 1,8-cineole,NADPH:oxygen oxidoreductase (2-exo-hydroxylating). This enzyme catalyses the following chemical reaction

: 1,8-cineole + NADPH + H+ + O2 \rightleftharpoons 2-exo-hydroxy-1,8-cineole + NADP+ + H2O

1,8-Cineole 2-exo-monooxygenase is a heme-thiolate protein (P-450).

References

References

  1. (February 2001). "Oxidation of 1,8-cineole, the monoterpene cyclic ether originated from eucalyptus polybractea, by cytochrome P450 3A enzymes in rat and human liver microsomes". Drug Metabolism and Disposition.
  2. (2001). "Biotransformation of 1,8-cineole by human liver microsomes". Natural Product Letters.
  3. (October 2001). "Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes". Xenobiotica; The Fate of Foreign Compounds in Biological Systems.
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