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Taurochenodeoxycholate 6α-hydroxylase

Class of enzymes

Field	Value
Name	Taurochenodeoxycholate 6alpha-hydroxylase
EC_number	1.14.13.97
CAS_number	105669-85-0

Taurochenodeoxycholate 6alpha-hydroxylase (, CYP3A4, CYP4A21, taurochenodeoxycholate 6alpha-monooxygenase) is an enzyme with systematic name taurochenodeoxycholate,NADPH:oxygen oxidoreductase (6alpha-hydroxylating). This enzyme catalyses the following chemical reaction

: (1) taurochenodeoxycholate + NADPH + H+ + O2 \rightleftharpoons taurohyocholate + NADP+ + H2O : (2) lithocholate + NADPH + H+ + O2 \rightleftharpoons hyodeoxycholate + NADP+ + H2O

Taurochenodeoxycholate 6α-hydroxylase is a heme-thiolate protein (P-450).

References

(April 1999). "6alpha-hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.
(August 1995). "Characterisation of taurochenodeoxycholic acid 6 alpha-hydroxylase from pig liver microsomes". European Journal of Biochemistry.
(March 2001). "Identification of the bile acid-binding site of the ileal lipid-binding protein by photoaffinity labeling, matrix-assisted laser desorption ionization-mass spectrometry, and NMR structure". The Journal of Biological Chemistry.
(March 2001). "Cloning and expression of a pig liver taurochenodeoxycholic acid 6alpha-hydroxylase (CYP4A21): a novel member of the CYP4A subfamily". The Journal of Biological Chemistry.
(November 2003). "Gene structure of pig sterol 12alpha-hydroxylase (CYP8B1) and expression in fetal liver: comparison with expression of taurochenodeoxycholic acid 6alpha-hydroxylase (CYP4A21)". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.
(2003). "The enzymes, regulation, and genetics of bile acid synthesis". Annual Review of Biochemistry.

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ec-1.14.13

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