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Stollé synthesis

Stollé synthesis

The Stollé synthesis is a series of chemical reactions that produce oxindoles from anilines and α-haloacid chlorides (or oxalyl chloride).

The Stollé synthesis

The first step is an amide coupling, while the second step is a Friedel–Crafts reaction. An improved procedure has been developed.

References

References

  1. Stollé, R.. (1913). "Über eine neue Methode zur Darstellung ''N''-substituierter Isatine. (Vorläufige Mitteilung)". [[Chemische Berichte.
  2. Stollé, R.. (1914). "Über Phenyl-oxindol". [[Chemische Berichte.
  3. (1922). "Über ''N''-substituierte Oxindole und Isatine". [[J. Prakt. Chem.]].
  4. (1930). "Über ''N''-substituierte Oxindole und Isatine". [[J. Prakt. Chem.]].
  5. Sumpter, Ward C.. (1944). "The Chemistry of Isatin". [[Chem. Rev.]].
  6. Sumpter, Ward C.. (1945). "The Chemistry of Oxindole". [[Chem. Rev.]].
  7. (1935). "Studies in the Indole Series. IV. The Synthesis of d,l-Eserethole". [[J. Am. Chem. Soc.]].
  8. (1950). "1-Methyl-3-ethyloxindole (Oxindole, 3-ethyl-1-methyl)".
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