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S-methyl-5'-thioinosine phosphorylase

Class of enzymes

Class of enzymes

FieldValue
NameS-methyl-5'-thioinosine phosphorylase
EC_number2.4.2.44

S-methyl-5'-thioinosine phosphorylase (, MTIP, MTI phosphorylase, methylthioinosine phosphorylase) is an enzyme with systematic name S-methyl-5'-thioinosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase. This enzyme catalyses the following chemical reaction

: S-methyl-5'-thioinosine + phosphate \rightleftharpoons hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate

The catabolism of 5'-methylthioadenosine in Pseudomonas aeruginosa involves deamination to S-methyl-5'-thioinosine (EC 3.5.4.31, S-methyl-5'-thioadenosine deaminase) and phosphorolysis to hypoxanthine.

References

References

  1. (February 2011). "Methylthioinosine phosphorylase from Pseudomonas aeruginosa. Structure and annotation of a novel enzyme in quorum sensing". Biochemistry.
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ec-2.4.2
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