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Rosenmund–von Braun reaction

Chemical reaction

Julius von Braun The Rosenmund–von Braun synthesis is an organic reaction in which an aryl halide reacts with cuprous cyanide to yield an aryl nitrile.

:[[Image:Rosenmund-von Braun synthesis.svg|Rosenmund–von Braun synthesis]]

The reaction was named after Karl Wilhelm Rosenmund who together with his Ph.D. student Erich Struck discovered in 1914 that aryl halide reacts with alcohol water solution of potassium cyanide and catalytic amounts of cuprous cyanide at 200 °C. The reaction yields the carboxylic acid, not the nitrile, but Rosenmund speculated that the intermediate should be the nitrile, since nitriles on aromatic rings can react to form carboxylic acids. and for example the use of ionic liquids as solvent for the reaction.

:[[File:Rosenmund-von-Braun-Reaktion.svg|thumb|500px|none|Other example]]

References

(27 September 1919). "Das am Ringkohlenstoff gebundene Halogen und sein Ersatz durch andere Substituenten. I. Mitteilung: Ersatz des Halogens durch die Carboxylgruppe". Berichte der Deutschen Chemischen Gesellschaft (A and B Series).
(1931). "Fluoranthen und seine Derivate. III. Mitteilung". Justus Liebig's Annalen der Chemie.
(1948). "9-CYANOPHENANTHRENE". Organic Syntheses.
(July 1927). "Untersuchungen über Perylen und seine Derivate". Monatshefte für Chemie.
(November 1941). "THE ROSENMUND-von BRAUN NITRILE SYNTHESIS". The Journal of Organic Chemistry.
(January 2002). "Catalytic Rosenmund–von Braun reaction in halide-based ionic liquids". Tetrahedron Letters.

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