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Multisite-specific tRNA:(cytosine-C5)-methyltransferase

FieldValue
NameMultisite-specific tRNA:(cytosine-C5)-methyltransferase
EC_number2.1.1.202

Multisite-specific tRNA:(cytosine-C5)-methyltransferase (, multisite-specific tRNA:m5C-methyltransferase, TRM4 (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (cytosine-C5)-methyltransferase. This enzyme catalyses the following chemical reaction

: (1) S-adenosyl-L-methionine + cytosine34 in tRNA precursor \rightleftharpoons S-adenosyl-L-homocysteine + 5-methylcytosine34 in tRNA precursor : (2) S-adenosyl-L-methionine + cytosine40 in tRNA precursor \rightleftharpoons S-adenosyl-L-homocysteine + 5-methylcytosine40 in tRNA precursor : (3) S-adenosyl-L-methionine + cytosine48 in tRNA \rightleftharpoons S-adenosyl-L-homocysteine + 5-methylcytosine48 in tRNA : (4) S-adenosyl-L-methionine + cytosine49 in tRNA \rightleftharpoons S-adenosyl-L-homocysteine + 5-methylcytosine49 in tRNA

The enzyme from Saccharomyces cerevisiae is responsible for complete 5-methylcytosine methylations of yeast tRNA.

References

References

  1. (August 1999). "Multisite-specific tRNA:m5C-methyltransferase (Trm4) in yeast Saccharomyces cerevisiae: identification of the gene and substrate specificity of the enzyme". RNA.
  2. (July 1997). "Pleiotropic effects of intron removal on base modification pattern of yeast tRNAPhe: an in vitro study". Nucleic Acids Research.
  3. (July 1986). "Effect of intron mutations on processing and function of Saccharomyces cerevisiae SUP53 tRNA in vitro and in vivo". Molecular and Cellular Biology.
  4. (July 2007). "Cysteine of sequence motif VI is essential for nucleophilic catalysis by yeast tRNA m5C methyltransferase". RNA.
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