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Ho–Kaufman–McAlister syndrome

Field	Value
synonym	Chen-Kung Ho–Kaufman–McAlister syndrome
specialty

Ho–Kaufman–McAlister syndrome is a rare congenital malformation syndrome where infants are born with a cleft palate, micrognathia, Wormian bones, congenital heart disease, dislocated hips, bowed fibulae, preaxial polydactyly of the feet, abnormal skin patterns, and most prominently, missing tibia. The etiology is unknown. Ho–Kaufman–McAlister syndrome is named after Chen-Kung Ho, R.L. Kaufman, and W.H. McAlister who first described the syndrome in 1975 at Washington University in St. Louis. It is considered a rare disease by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH).

References

Ho–Kaufman–McAlister Syndrome Summary at PubMed

Ho CK, Kaufman RL, McAlister WH (1975). "Congenital Malformations: Cleft Palate, Congenital Heart Disease, Absent Tibiae, and Polydactyly." American Journal of Diseases of Children 1975 Jun. 129(6):714–6.

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congenital-disorders syndromes syndromes-affecting-the-heart syndromes-affecting-the-jaw

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