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Etidocaine

Etidocaine, marketed under the trade name Duranest, is an amide-type local anesthetic given by injection during surgical procedures and labor and delivery. Etidocaine has a long duration of activity, and the main disadvantage of use during dentistry is increased bleeding during surgery.

Column 1

Duranest
Micromedex Detailed Consumer Information
a603026
.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}
AU: B1
Parenteral
N01BB07 (WHO)
US: ℞-only
n/a
Hepatic
2.5 hours
Renal
IUPAC name
N-(2,6-dimethylphenyl)-2-(ethyl(propyl)amino)butanamide
36637-18-0 N
37497
2621
DB08987 N
34400 Y
I6CQM0F31V
D04095 Y
CHEBI:4904 Y
ChEMBL492 Y
DTXSID1023027
100.048.296
C17H28N2O
276.424 g·mol−1
Interactive image
SMILES
O=C(Nc1c(C)cccc1C)C(CC)N(CC)CCC
InChI
InChI=1S/C17H28N2O/c1-6-12-19(8-3)15(7-2)17(20)18-16-13(4)10-9-11-14(16)5/h9-11,15H,6-8,12H2,1-5H3,(H,18,20) YKey:VTUSIVBDOCDNHS-UHFFFAOYSA-N Y
.mw-parser-output .nobold{font-weight:normal} NY (what is this?) (verify)

Etidocaine, marketed under the trade name Duranest, is an amide-type local anesthetic given by injection during surgical procedures and labor and delivery. Etidocaine has a long duration of activity, and the main disadvantage of use during dentistry is increased bleeding during surgery.

Patent: 2-bromobutyryl chloride synthesis:

The amide reaction between 2,6-xylidine (1) and 2-bromobutyryl chloride [22118-12-3] (2) gives 2-Bromo-N-(2,6-Dimethylphenyl)Butanamide [53984-81-9] (3). Alkylation with N-Ethylpropylamine [20193-20-8] (4) gives Etidocaine (5).

Duranest (RxList)

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