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Buclizine

Buclizine is an antihistamine and anticholinergic of the diphenylmethylpiperazine group. It is considered to be an antiemetic, similar to meclizine.

Column 1

Micromedex Detailed Consumer Information
.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}R06AE01 (WHO)
IUPAC name
(RS)-1-[(4-chlorophenyl)- phenyl-methyl]-4- [(4-tert-butylphenyl) methyl] piperazine
82-95-1 Y
6729
7134
DB00354 Y
6473 Y
0C94V6X681
CHEBI:3205 Y
ChEMBL1201271 N
DTXSID0022694
100.001.317
C28H33ClN2
433.04 g·mol−1
Interactive image
Racemic mixture
SMILES
Clc1ccc(cc1)C(c2ccccc2)N3CCN(CC3)Cc4ccc(cc4)C(C)(C)C
InChI
InChI=1S/C28H33ClN2/c1-28(2,3)25-13-9-22(10-14-25)21-30-17-19-31(20-18-30)27(23-7-5-4-6-8-23)24-11-15-26(29)16-12-24/h4-16,27H,17-21H2,1-3H3 YKey:MOYGZHXDRJNJEP-UHFFFAOYSA-N Y
.mw-parser-output .nobold{font-weight:normal} NY (what is this?) (verify)

Buclizine is an antihistamine and anticholinergic of the diphenylmethylpiperazine group. It is considered to be an antiemetic, similar to meclizine.

In the United Kingdom, buclizine is one of three drugs contained in Migraleve tablets, marketed by McNeil Healthcare for migraines.

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