Surf Wiki
Save to docs
general

From Surf Wiki (app.surf) — the open knowledge base

8-OH-DPAT

Column 1
8-Hydroxy-2-(dipropylamino)tetralin; 8-Hydroxy-2-(di-n-propylamino)tetralin
Serotonin 5-HT1A receptor agonist; Serotonin 5-HT7 receptor agonist; Serotonin reuptake inhibitor or releasing agent
.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}None
IUPAC name
7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol
78950-78-4 Y
1220
7
1183 Y
IWS1724PX6
CHEBI:73364 N
ChEMBL56 Y
DTXSID30897384
C16H25NO
247.382 g·mol−1
Interactive image
SMILES
CCCN(CCC)C1CCc2cccc(O)c2C1
InChI
InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3 YKey:ASXGJMSKWNBENU-UHFFFAOYSA-N Y
.mw-parser-output .nobold{font-weight:normal} NY (what is this?)  (verify)

8-OH-DPAT, also known as 8-hydroxy-2-(dipropylamino)tetralin, is a serotonin 5-HT1A receptor agonist of the 2-aminotetralin family which was developed in the 1980s and has been widely used to study the function of the 5-HT1A receptor. It was one of the first major 5-HT1A receptor full agonists to have been discovered.

Originally believed to be selective for the 5-HT1A receptor, 8-OH-DPAT was later found to act as a serotonin 5-HT7 receptor agonist and serotonin reuptake inhibitor or releasing agent as well.

In animal studies, 8-OH-DPAT has been shown to possess antidepressant, anxiolytic, serenic (antiaggressive), anorectic, antiemetic, hypothermic, hypotensive, bradycardic, hyperventilative, and analgesic effects.

  • Substituted 2-aminotetralin

  • 5-OH-DPAT

  • 5-MeO-DPAC

  • 7-OH-DPAT

  • Bay R 1531

  • MDAT

  • RDS-127

  • UH-301

  • PAT (8-OH-DPAT) - The Shulgin Index

Want to explore this topic further?

Ask Mako anything about 8-OH-DPAT — get instant answers, deeper analysis, and related topics.

Research with Mako

Free with your Surf account

Content sourced from Wikipedia, available under CC BY-SA 4.0.

This content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.

Report