From Surf Wiki (app.surf) — the open knowledge base
7-Methylguanine
| Column 1 | Column 2 |
|---|---|
| IUPAC name | |
| 7-Methylguanine | |
| Preferred IUPAC name | |
| 2-Amino-7-methyl-1,7-dihydro-6H-purin-6-one | |
| Other names | |
| N7-Methylguanine; Epiguanine | |
| CAS Number | .mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}578-76-7 Y[Pubchem] |
| 3D model (JSmol) | Interactive image |
| Beilstein Reference | 174245 |
| ChEBI | CHEBI:2274 Y |
| ChemSpider | 10883 Y |
| ECHA InfoCard | 100.008.575 |
| EC Number | 209-431-0 |
| KEGG | C02242 |
| PubChem CID | 135398679 |
| UNII | 661J4K04NB |
| CompTox Dashboard (EPA) | DTXSID9020873 |
| InChI | |
| InChI=1S/C6H7N5O/c1-11-2-8-4-3(11)5(12)10-6(7)9-4/h2H,1H3,(H3,7,9,10,12)Key: FZWGECJQACGGTI-UHFFFAOYSA-N | |
| SMILES | |
| CN1C=NC2=C1C(=O)N=C(N2)N | |
| Chemical formula | C6H7N5O |
| Molar mass | 165.156 g·mol−1 |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| N verify (what is YN ?) |
Infobox references | |
7-Methylguanine is a modified purine nucleobase. It is a methylated version of guanine. The 7-methylguanine nucleoside is called 7-methylguanosine. However, the free 7-methylguanine base is not involved in the synthesis of nucleotides and not incorporated directly into nucleic acids. 7-Methylguanine is a natural inhibitor of poly (ADP-ribose) polymerase (PARP) and tRNA guanine transglycosylase (TGT) - and thus may exert anticancer activity. For example, it was demonstrated that 7-methylguanine could accelerate apoptotic death of BRCA1-deficient breast cancer cells induced by cisplatin and doxorubicin.
Ask Mako anything about 7-Methylguanine — get instant answers, deeper analysis, and related topics.
Research with MakoFree with your Surf account
Create a free account to save articles, ask Mako questions, and organize your research.
Sign up freeThis content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.
Report