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5-Iodowillardiine
| Column 1 | Column 2 |
|---|---|
| IUPAC name | |
| (2S)-2-Amino-3-(5-iodo-2,4-dioxopyrimidin-1-yl)propanoic acid | |
| CAS Number | .mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}140187-25-3 N |
| 3D model (JSmol) | Interactive imageInteractive image |
| ChEMBL | ChEMBL121915 Y |
| ChemSpider | 394358 Y |
| DrugBank | DB02818 Y |
| IUPHAR/BPS | 4071 |
| PubChem CID | 447196 |
| CompTox Dashboard (EPA) | DTXSID90332246 |
| InChI | |
| InChI=1S/C7H8IN3O4/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12/h1,4H,2,9H2,(H,13,14)(H,10,12,15)/t4-/m0/s1 YKey: AXXYLTBQIQBTES-BYPYZUCNSA-N YInChI=1/C7H8IN3O4/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12/h1,4H,2,9H2,(H,13,14)(H,10,12,15)/t4-/m0/s1Key: AXXYLTBQIQBTES-BYPYZUCNBL | |
| SMILES | |
| C1=C(C(=O)NC(=O)N1CC@@HN)IO=C(O)C@@HCN1/C=C(/I)C(=O)NC1=O | |
| Chemical formula | C7H8IN3O4 |
| Molar mass | 325.061 g/mol |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| N verify (what is YN ?) |
Infobox references | |
5-Iodowillardiine is a selective agonist for some kainate receptor subunits with only limited effects at AMPA receptors. It activates kainate receptors containing GluK1 (GluR5) or GluK5 (KA2) subunits, but it does not act on GluK2 (GluR6) subunits. It is an excitotoxic neurotoxin in vivo, but has proved highly useful for characterising the subtypes and function of the various kainate receptors in the brain and spinal cord.
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