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4-DAMP
| Column 1 | Column 2 |
|---|---|
| Preferred IUPAC name | |
| 4-[(Diphenylacetyl)oxy]-1,1-dimethylpiperidin-1-ium iodide | |
| Other names | |
| 4-(2,2-Diphenylacetoxy)-1,1-dimethylpiperidin-1-ium iodide | |
| CAS Number | .mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}1952-15-4 Y |
| 3D model (JSmol) | Interactive image |
| ChemSpider | 2282596 |
| PubChem CID | 3014059 |
| UNII | CP6GVV66RG Y |
| CompTox Dashboard (EPA) | DTXSID40941281 |
| InChI | |
| InChI=1S/C21H26NO2.HI/c1-22(2)15-13-19(14-16-22)24-21(23)20(17-9-5-3-6-10-17)18-11-7-4-8-12-18;/h3-12,19-20H,13-16H2,1-2H3;1H/q+1;/p-1Key: WWJHRSCUAQPFQO-UHFFFAOYSA-M | |
| SMILES | |
| [I-].C[N+]1(C)CCC(CC1)OC(=O)C(C1=CC=CC=C1)C1=CC=CC=C1 | |
| Chemical formula | C21H26INO2 |
| Molar mass | 451.348 g·mol−1 |
| Appearance | White to beige powder |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). |
Infobox references | |
4-DAMP (1,1-dimethyl-4-diphenylacetoxypiperidinium iodide) is a selective muscarinic acetylcholine receptor (mAChR) M3 antagonist. It is also able to antagonize M1 receptors but has preferential activity at the M3 receptor. It competitively binds to the acetylcholine binding site on mAChRs, causing right-ward shift in the dose response curves for mAChR agonists.
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