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2C-Se-TFM


Column 1
IUPAC name
4-trifluoromethylselanyl-2,5-dimethoxyphenethylamine
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C11H14F3NO2Se
328.204 g·mol−1
Interactive image
SMILES
NCCc1cc(OC)c(cc1OC)[Se]C(F)(F)F
InChI
InChI=1S/C11H14F3NO2Se/c1-16-8-6-10(18-11(12,13)14)9(17-2)5-7(8)3-4-15/h5-6H,3-4,15H2,1-2H3Key:ODGBUUUVMLDZBP-UHFFFAOYSA-N

2C-Se-TFM is a designer drug from the substituted phenethylamine family, which produces psychedelic-like effects in animals such as a head twitch response. It was first synthesised by Josh Hartsel and colleagues in 2024. It has a binding affinity (Ki) of 3.2 nM at the serotonin receptor 5-HT2A and an EC50 of 3.6 nM, acting as a full agonist. Aside from 2C-Se, it is the only psychedelic drug containing a selenium atom, as while other related analogues such as the ethyl compound 2C-Se-2 and the propyl derivative 2C-Se-7 have been proposed as theoretical compounds, neither is known to have been synthesised. It is a controlled substance in Canada under phenethylamine blanket-ban language.

  • 2C (psychedelics)
  • 2C-TFE
  • 2C-T-4
  • 2C-T-21
  • 2C-T-TFM
  • 2C-Te
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