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25P-NBOMe
| Column 1 |
|---|
| 2C-P-NBOMe; NBOMe-2C-P; N-(2-Methoxybenzyl)-4-propyl-2,5-dimethoxyphenethylamine |
| Serotonin 5-HT2 receptor agonist; Serotonergic psychedelic; Hallucinogen |
| .mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0} |
| BR: Class F2 (Prohibited psychotropics) |
| DE: NpSG (Industrial and scientific use only) |
| UK: Class A |
| IUPAC name |
| 2-(4-propyl-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine |
| 1391489-07-8 |
| 118796470 |
| 52085310 Y |
| 71505RK15Z |
| DTXSID801014185 |
| C21H29NO3 |
| 343.467 g·mol−1 |
| Interactive image |
| SMILES |
| CCCC1=CC(OC)=C(CCNCC2=C(OC)C=CC=C2)C=C1OC |
| InChI |
| InChI=1S/C21H29NO3/c1-5-8-16-13-21(25-4)17(14-20(16)24-3)11-12-22-15-18-9-6-7-10-19(18)23-2/h6-7,9-10,13-14,22H,5,8,11-12,15H2,1-4H3 YKey:QHEBYIJRKGDFGH-UHFFFAOYSA-N Y |
25P-NBOMe (2C-P-NBOMe, NBOMe-2C-P) is a derivative of the phenethylamine 2C-P. It acts in a similar manner to related compounds such as 25I-NBOMe, which are potent agonists at the 5-HT2A receptor. 25P-NBOMe has been sold as a drug and produces similar effects in humans to related compounds such as 25I-NBOMe and 25C-NBOMe.
The dose range of 25P-NBOMe has been given as 0.1 to 1.5 mg sublingually, with a typical dose estimate of 0.6 mg.
| Target | Affinity (Ki, nM) |
|---|---|
| 5-HT1A | 1,800 |
| 5-HT1B | ND |
| 5-HT1D | ND |
| 5-HT1E | ND |
| 5-HT1F | ND |
| 5-HT2A | 0.630–1.1 (Ki)63.0–220 (EC50Tooltip half-maximal effective concentration)42–94% (EmaxTooltip maximal efficacy) |
| 5-HT2B | 20.0 (Ki)170 (EC50)23% (Emax) |
| 5-HT2C | 6.0 (Ki)25.1 (EC50)109% (Emax) |
| 5-HT3 | ND |
| 5-HT4 | ND |
| 5-HT5A | 5,100 |
| 5-HT6 | 140.8 |
| 5-HT7 | 2,905 |
| α1A | 310 |
| α1B, α1D | ND |
| α2A | 410 |
| α2B, α2C | ND |
| β1–β3 | ND |
| D1 | 3,100 |
| D2 | 870 |
| D3 | 2,300 |
| D4, D5 | ND |
| H1 | 1,700 |
| H2–H4 | ND |
| M1–M5 | ND |
| I1 | ND |
| σ1, σ2 | ND |
| ORs | ND |
| TAAR1Tooltip Trace amine-associated receptor 1 | 240 (Ki) (mouse)55–60 (Ki) (rat)1,300 (EC50) (mouse)510 (EC50) (rat)>10,000 (EC50) (human)40% (Emax) (mouse)34% (Emax) (rat) |
| SERTTooltip Serotonin transporter | 5,200 (Ki)12,000 (IC50Tooltip half-maximal inhibitory concentration)ND (EC50) |
| NETTooltip Norepinephrine transporter | 2,800 (Ki)14,000 (IC50)ND (EC50) |
| DATTooltip Dopamine transporter | 4,700 (Ki)82,000 (IC50)ND (EC50) |
| Notes: The smaller the value, the more avidly the drug binds to the site. All proteins are human unless otherwise specified. Refs: |
25P-NBOMe is a potent agonist of the serotonin 5-HT2 receptors, including the serotonin 5-HT2A receptor.
25P-NBOMe was first described in the scientific literature by 2012.
25P-NBOMe is a controlled substance in Canada under phenethylamine blanket-ban language.
This substance is a Class A drug in the United Kingdom as a result of the N-benzylphenethylamine catch-all clause in the Misuse of Drugs Act 1971.
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25-NB
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2C-P
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25P-NBOMe - Isomer Design
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The Small & Fancy 25P-NBOMe Thread - Bluelight
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