Surf Wiki
Save to docs
general/ec-1-14-13

From Surf Wiki (app.surf) — the open knowledge base

25-hydroxycholesterol 7α-hydroxylase

Class of enzymes

Class of enzymes

FieldValue
Name25-hydroxycholesterol 7alpha-hydroxylase
EC_number1.14.13.100

25-hydroxycholesterol 7alpha-hydroxylase (, 25-hydroxycholesterol 7alpha-monooxygenase, CYP7B1, CYP7B1 oxysterol 7alpha-hydroxylase) is an enzyme with systematic name cholest-5-ene-3beta,25-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating). This enzyme catalyses the following chemical reaction

: (1) cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 \rightleftharpoons cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O : (2) cholest-5-ene-3beta,27-diol + NADPH + H+ + O2 \rightleftharpoons cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O

25-hydroxycholesterol 7α-hydroxylase is a heme-thiolate protein (P-450).

References

References

  1. (September 1994). "7 alpha hydroxylation of 25-hydroxycholesterol in liver microsomes. Evidence that the enzyme involved is different from cholesterol 7 alpha-hydroxylase". European Journal of Biochemistry.
  2. (June 2000). "Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol". The Journal of Biological Chemistry.
  3. (May 2003). "Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in the rat". Metabolism.
  4. (2003). "The enzymes, regulation, and genetics of bile acid synthesis". Annual Review of Biochemistry.
Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

ec-1.14.13
Want to explore this topic further?

Ask Mako anything about 25-hydroxycholesterol 7α-hydroxylase — get instant answers, deeper analysis, and related topics.

Research with Mako

Free with your Surf account

Content sourced from Wikipedia, available under CC BY-SA 4.0.

This content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.

Report