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23S rRNA (uridine2552-2'-O)-methyltransferase

Class of enzymes

Field	Value
Name	23S rRNA (uridine2552-2'-O)-methyltransferase
EC_number	2.1.1.166

23S rRNA (uridine2552-2'-O)-methyltransferase (, Um(2552) 23S ribosomal RNA methyltransferase, heat shock protein RrmJ, RrmJ, FTSJ, Um2552 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (uridine2552-2'-O-)-methyltransferase. This enzyme catalyses the following chemical reaction

: S-adenosyl-L-methionine + uridine2552 in 23S rRNA \rightleftharpoons S-adenosyl-L-homocysteine + 2'-O-methyluridine2552 in 23S rRNA

The enzyme catalyses the 2'-O-methylation of the universally conserved U2552 in the A loop of 23S rRNA.

References

(June 2000). "The FtsJ/RrmJ heat shock protein of Escherichia coli is a 23 S ribosomal RNA methyltransferase". The Journal of Biological Chemistry.
(November 2002). "Active site in RrmJ, a heat shock-induced methyltransferase". The Journal of Biological Chemistry.
(October 2004). "Substrate binding analysis of the 23S rRNA methyltransferase RrmJ". Journal of Bacteriology.
(August 2000). "RNA methylation under heat shock control". Molecular Cell.

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This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

ec-2.1.1

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