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23S rRNA (uridine2479-2'-O)-methyltransferase

Class of enzymes

Class of enzymes

FieldValue
Name23S rRNA (uridine2479-2'-O)-methyltransferase
EC_number2.1.1.208

23S rRNA (uridine2479-2'-O)-methyltransferase (, AviRb) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (uridine2479-2'-O)-methyltransferase. This enzyme catalyses the following chemical reaction

: S-adenosyl-L-methionine + uridine2479 in 23S rRNA \rightleftharpoons S-adenosyl-L-homocysteine + 2'-O-methyluridine2479 in 23S rRNA

Streptomyces viridochromogenes produces the antibiotic avilamycin A which binds to the 50S ribosomal subunit to inhibit protein synthesis.

References

References

  1. (January 2005). "Structure and function of the antibiotic resistance-mediating methyltransferase AviRb from Streptomyces viridochromogenes". Journal of Molecular Biology.
  2. (July 2003). "The avilamycin resistance determinants AviRa and AviRb methylate 23S rRNA at the guanosine 2535 base and the uridine 2479 ribose". Molecular Microbiology.
  3. (March 2001). "An ATP-binding cassette transporter and two rRNA methyltransferases are involved in resistance to avilamycin in the producer organism Streptomyces viridochromogenes Tü57". Antimicrobial Agents and Chemotherapy.
  4. (November 2016). "Avilamycin and evernimicin induce structural changes in rProteins uL16 and CTC that enhance the inhibition of A-site tRNA binding". Proceedings of the National Academy of Sciences of the United States of America.
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