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23S rRNA (cytidine1920-2'-O)-methyltransferase

Class of enzymes

Field	Value
Name	23S rRNA (cytidine1920-2'-O)-methyltransferase
EC_number	2.1.1.226

23S rRNA (cytidine1920-2'-O)-methyltransferase (, TlyA) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (cytidine1920-2'-O)-methyltransferase. This enzyme catalyses the following chemical reaction

: S-adenosyl-L-methionine + cytidine1920 in 23S rRNA \rightleftharpoons S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 23S rRNA

This is a bifunctional enzyme from Mycobacterium tuberculosis.

References

(July 2006). "Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2'-O-methylations in 16S and 23S rRNAs". Molecular Cell.
(February 2005). "Mutation of tlyA confers capreomycin resistance in Mycobacterium tuberculosis". Antimicrobial Agents and Chemotherapy.

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ec-2.1.1

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